Debuting in 2008, the first-generation Audi A5-derived Q5 (chassis code 8R) quickly became a global bestseller in the mid-size premium crossover market. Engineering on the MLP platform allowed a long wheelbase, short overhangs, and a clean exterior shape capped by a wrap-around aluminum tailgate. Structural rigidity and cabin noise insulation were praised.

Engine options included 2.0 TFSI, 3.2 FSI V6, 3.0 TFSI petrols, and 2.0 TDI / 3.0 TDI V6 diesels. Power reached all four wheels via permanent Torsen-based quattro (40:60 default split) through 7-speed S tronic or 8-speed Tiptronic automatics. In 2011, Audi introduced the Q5 Hybrid quattro, marking Audi's first production hybrid vehicle. The model fully reflected the premium status of the automaker and its commitment to technological leadership in its class. The model fully reflected the premium status of the automaker and its commitment to technological leadership in its class.