The second generation Cadillac SRX debuted in 2009 constructed on the front-wheel-drive Theta Premium platform. Shifting to a dedicated five-passenger configuration with compact dimensions, it adopted sharp exterior character lines highlighted by chrome fender vents and iconic vertical LED tailfin lamps. The model quickly became Cadillac's best-selling passenger model globally throughout its production lifespan. The exterior design incorporates distinctive body proportions, sharp character lines, and an iconic front grille featuring the brand's emblem.

Launch engines included a 3.0-liter V6 (265 hp) and a 2.8-liter turbocharged V6 (300 hp), consolidated for 2012 into a single 308-horsepower 3.6-liter V6 paired with a 6-speed automatic transmission. The available e-AWD system featured an active electronic limited-slip rear differential (eLSD). A 2013 mid-cycle update added Cadillac CUE touchscreen infotainment and active driver assistance safety tech. Standard and optional equipment included advanced active and passive safety systems, multi-zone climate control, and upgraded interior electronics. Standard and optional equipment included advanced active and passive safety systems, multi-zone climate control, and upgraded interior electronics.