Debuting for 2008, the second-generation Escape retained the established unibody layout while introducing totally redesigned exterior sheet metal. Styling echoed the tough look of the Explorer with a prominent chrome grille and squared-off headlamps. The refreshed cabin featured updated seating, acoustic glass, and Ford's Ice Blue interior lighting.

Powertrain upgrades introduced a 171-hp 2.5-liter four-cylinder and an updated 240-hp 3.0-liter V6, paired with a new six-speed automatic transmission. The Escape Hybrid model maintained strong fleet and taxi popularity due to its proven durability and exceptional city fuel economy. The lasting engineering impact of this generation remains a key benchmark in Ford's global model evolution history. Known for its dependable mechanical layout, the vehicle built a loyal customer base across diverse driving conditions. Offered with versatile feature packages, this iteration successfully balanced day-to-day usability with solid resale value.