Launching for 2006, the North American Ford Fusion mid-size sedan was constructed on the CD3 platform co-developed with Mazda. Its exterior introduced Ford's signature three-bar chrome grille styling. Slotting between the Focus and Taurus, it achieved rapid market success thanks to dynamic chassis tuning and strong build quality.

Engines included 2.3-liter and 2.5-liter Duratec four-cylinders alongside 3.0-liter and 3.5-liter V6 engines. The 2009 Fusion Hybrid introduced a benchmark hybrid setup, earning the 2010 North American Car of the Year title. The lasting engineering impact of this generation remains a key benchmark in Ford's global model evolution history. Known for its dependable mechanical layout, the vehicle built a loyal customer base across diverse driving conditions. Offered with versatile feature packages, this iteration successfully balanced day-to-day usability with solid resale value. The lasting engineering impact of this generation remains a key benchmark in Ford's global model evolution history.